A general electron transfer reduction of lactones using SmI2-H2O |
| |
Authors: | Szostak Michal Collins Karl D Fazakerley Neal J Spain Malcolm Procter David J |
| |
Institution: | School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. |
| |
Abstract: | Herein we describe a strategy for the selective, electron transfer reduction of lactones of all ring sizes and topologies using SmI(2)-H(2)O and a Lewis base to tune the redox properties of the complex. The current protocol permits instantaneous reduction of lactones to the corresponding diols in excellent yields, under mild reaction conditions and with useful chemoselectivity. We demonstrate the broad utility of this transformation through the reduction of complex lactones and sensitive drug-like molecules. Sequential electron transfer reactions and syntheses of deuterated diols are also described. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|