Two diketopiperazine cyclo(pro-phe) isomers from marine bacteria <Emphasis Type="Italic">Bacillus subtilis</Emphasis> sp. 13-2 |
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Authors: | Guanghua Wang Shikun Dai Minjie Chen Houbuo Wu Lianwu Xie Xiongming Luo Xiang Li |
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Institution: | (1) Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, P. R. China;(2) Graduate University of Chinese Academy of Sciences, Beijing, 100049, P. R. China; |
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Abstract: | Two bioactive diketopiperazines, cyclo(S-Pro-S-Phe) and cyclo(R-Pro-S-Phe), against Bacillus subtilis (terrestrial), Staphylococcus
aureus, and Escherichia coli DH5a were isolated from marine surface sediment bacteria Bacillus subtilis sp.13-2. To our knowledge,
this was the first time that cyclo(S-Pro-S-Phe) and cyclo(R-Pro-S-Phe) were isolated from Bacillus subtilis, and the first
time that cyclo(R-Pro-S-Phe) was isolated from a natural source. These two compounds were established on the basis of ESI-MS
spectral data, as well as NMR 1D and 2D (COSY, HMQC, and HMBC) spectral data. |
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