Novel lactonization of ethenetricarboxylate derivatives: intermolecular trapping of alkenes |
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| Authors: | Yamazaki Shoko Ohmitsu Kanae Ohi Kunihiro Otsubo Tetsuya Moriyama Kayo |
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| Institution: | Department of Chemistry, Nara University of Education, Takabatake-cho, Nara 630-8528, Japan. yamazaks@nara-edu.ac.jp |
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| Abstract: | A novel cyclization of 1,1-diethyl 2-tert-butyl ethenetricarboxylate (1a) in the presence of a Lewis acid afforded a 5,5-dimethyl-gamma-lactone derivative 2a. The reaction process has been shown to arise from formation by trapping of isobutylene generated in situ. Lewis acid-promoted intermolecular reactions of 1,1-diethyl 2-hydrogen ethenetricarboxylate (5) and various alkenes to afford highly functionalized gamma-lactones were also developed. reaction: see text] |
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