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Microwave assisted sulfopropylation of N-heterocycles using 1,3-propane sultone |
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| Authors: | Maciej Adamczyk Sushil Rege |
| Institution: | Divisional Organic Chemistry (9NM/AP20), Abbott Laboratories, 100 Abbott Park Rd., Abbott Park, IL 60064, USA |
| Abstract: | Dramatic rate acceleration was observed for N-sulfopropylation of heterocyclic compounds (1a-h) using 1,3-propane sultone(2) under microwave irradiation affording the N-sulfopropylated compounds (3a-h) in 68–95% yield. |
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