| 酸促进2-乙烯基苯胺与重氮的[5+1]环化合成2-芳基喹啉 |
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| 引用本文： | 南江,陈璞,马养民.酸促进2-乙烯基苯胺与重氮的[5+1]环化合成2-芳基喹啉[J].高等学校化学学报,2020,41(11):2457. |
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| 作者姓名： | 南江 陈璞 马养民 |
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| 作者单位： | 陕西科技大学化学与化工学院, 中国轻工业轻化工助剂重点实验室, 西安 710021 |
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| 基金项目： | 国家自然科学基金(21801159);陕西省自然科学基金(2020JQ-705) |
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| 摘 要： | 利用廉价易得的2-乙烯基苯胺与重氮化合物在三氟乙酸催化下发生5+1]环化反应, 以中等至良好的产率合成了24种2-芳基喹啉衍生物. 该方法无需金属催化剂, 官能团兼容性好, 反应成本低, 不仅拓展了重氮化合物参与的新型有机反应, 同时也为2-芳基取代喹啉的合成提供了高效、 经济且简洁的新方法.
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| 关 键 词： | 酸促进[5+1]环化 无金属催化 2-芳基喹啉 |
| 收稿时间： | 2020-06-10 |
Acid-promoted ［5+1］ Annulation of 2-Vinylanilines with Diazo Compounds to 2-Arylquinolines |
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| NAN Jiang,CHEN Pu,MA Yangmin.Acid-promoted ［5+1］ Annulation of 2-Vinylanilines with Diazo Compounds to 2-Arylquinolines[J].Chemical Research In Chinese Universities,2020,41(11):2457. |
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| Authors: | NAN Jiang CHEN Pu MA Yangmin |
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| Institution: | College of Chemistry & Chemical Engineering，Key Laboratory of Chemical Additives for China National Light Industry，Shaanxi University of Science and Technology，Xi’an 710021，China |
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| Abstract: | An acid-promoted ［5+1］ annulation of 2-vinylanilines with diazo compounds for the synthesis of 2-arylquinolines was developed. The strategy applies cheap and available anilines and diazo compounds as substrates， and generates 24 kinds of 2-arylquinolines in metal-free catalysis with excellent functional group tole-rance in moderate to good yields. This method not only provides an efficient， economical and simple approach for the synthesis of 2-arylquinolines， but also enriches the organic reactions of diazo compounds. |
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| Keywords: | Acid-promoted ［5+1］ annulation Metal-free catalysis 2-Arylquinoline |
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