| Synthesis and cytotoxic activity of 3-phenyl-4-substituted-β-carbolines |
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| 作者姓名： | Liu Liu Ying Ying Xu Ze Qi Yang Jian Nan Xiang Guang Yu Xu |
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| 作者单位： | Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China ; College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China |
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| 基金项目： | supported by NSFC(No.20602010);Scientific Research Fund of Hunan Provincial Education Department(No.10B061) and Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province |
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| 摘 要： | A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro.It was found that some of the tested compounds showed better cytotoxicity against HeLa and MCF-7 cells than harmine.
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| 关 键 词： | β-Carboline Synthesis Iodine-mediated cyclization Cytotoxicity Harmine |
| 收稿时间： | 11 July 2012 |
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