A comprehensive approach to method validation based on object technology |
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Authors: | M H Feinberg Alice Gerbanowski D N Rutledge |
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Institution: | (1) Institut National de la Recherche Agronomique (INRA), Laboratoire de Chimie analytique, 16 rue Claude Bernard, F-75231 Paris CEDEX 05, France Tel.: +33 1 44 08 16 45; Fax: +33 1 44 08 16 60; e-mail: ciqual@inapg.inra.fr, FR |
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Abstract: | Method validation procedure requires a strategy for collecting those validation data that are best adapted to the analytical
technique used. A flexible and general approach based on Object Linking and Embedding technology is proposed. It allows a
traceable validation strategy using modular objects which encapsulate documentation, analytical data and processing logic.
The contents of these objects are accessible through a standard user interface. This paper demonstrates how this can reduce
experiment time, simplify evaluation efforts, and increase the ease of use of validation figures of merit. An illustration
using Microsoft Visual Basic for Applications is presented, and some specific aspects are described. It consists of the evaluation
of a time domain NMR technique for determining the moisture content of foods involving a multivariate calibration step. This
study also illustrates how guidelines such as Good Validation Practices could be defined to present all validation documents
in a standardised manner.
Received: 3 September 1996 Accepted: 14 October 1996 |
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Keywords: | Method validation Computer techniques Object linking and embedding technology Spreadsheet |
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