A Review of HER4 (ErbB4) Kinase,Its Impact on Cancer,and Its Inhibitors |
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| Authors: | Mohammed I El-Gamal Nada H Mewafi Nada E Abdelmotteleb Minnatullah A Emara Hamadeh Tarazi Rawan M Sbenati Moustafa M Madkour Seyed-Omar Zaraei Afnan I Shahin Hanan S Anbar |
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| Institution: | 1.College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates; (N.H.M.); (N.E.A.); (M.A.E.); (H.T.);2.Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates; (R.M.S.); (M.M.M.); (S.-O.Z.); (A.I.S.);3.Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt;4.Department of Clinical Pharmacy and Pharmacotherapeutics, Dubai Pharmacy College for Girls, Dubai 19099, United Arab Emirates |
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| Abstract: | HER4 is a receptor tyrosine kinase that is required for the evolution of normal body systems such as cardiovascular, nervous, and endocrine systems, especially the mammary glands. It is activated through ligand binding and activates MAPKs and PI3K/AKT pathways. HER4 is commonly expressed in many human tissues, both adult and fetal. It is important to understand the role of HER4 in the treatment of many disorders. Many studies were also conducted on the role of HER4 in tumors and its tumor suppressor function. Mostly, overexpression of HER4 kinase results in cancer development. In the present article, we reviewed the structure, location, ligands, physiological functions of HER4, and its relationship to different cancer types. HER4 inhibitors reported mainly from 2016 to the present were reviewed as well. |
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| Keywords: | HER4 ErbB4 cancer kinase inhibitors structure-activity relationship |
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