The use of vibrational spectroscopy to study the pathogenesis multiple sclerosis and other neurological conditions |
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| Authors: | Inês R. Ramos Fiona M. Lyng Ihtesham Ur Rehman Basil Sharrack M. Nicola Woodroofe |
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| Affiliation: | 1. Biomolecular Sciences Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, UK;2. DIT Centre for Radiation and Environmental Science, Focas Research Institute, Dublin Institute of Technology, Dublin, Ireland;3. Department of Materials Science and Engineering, The Kroto Research Institute, Sheffield, UK;4. Sheffield Teaching Hospital Foundation Trust, Academic Department of Neurology;5. The University of Sheffield, Sheffield Institute for Translational Neuroscience and the Sheffield NIHR Biomedical Research Centre for Translational Neuroscience |
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| Abstract: | Spectroscopy techniques are valuable tools in biomedical research and have been used extensively in the study of disease. However, neurological conditions such as multiple sclerosis (MS) have received little attention and the available spectroscopy studies are limited, both in overall numbers of patients studied and the disease samples considered. MS is a complex immune-mediated disease, with variable clinical courses and limited therapeutic options. This review aims to summarize current literature in the area, demonstrating how spectroscopy techniques can provide valuable information to inform and advance research into the most common neurological condition affecting young adults. |
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| Keywords: | Multiple sclerosis normal-appearing white matter pathology spectroscopy |
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