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Photo-induced DNA cleavage by (heterocyclo)carbonyl oxime esters of anthraquinone |
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| Authors: | Jih Ru Hwu Jhih-Ren Yang Ming-Hua Hsu Shang-Shing P. Chou |
| Affiliation: | a Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC b Department of Chemistry, National Central University, Jhongli 32001, Taiwan, ROC c Department of Chemistry, Fu Jen Catholic University, 24205, Taiwan, ROC |
| Abstract: | Various (heterocyclo)carbonyl mono-oxime esters of anthraquinone were synthesized, which exhibited an ability for DNA cleavage upon UV irradiation. Their structure-activity relationship was established, in which the most potent compound was anthraquinone O-9-(1,3-benzothiazole-2-carbonyl)oxime (4j). It can produce radical species and nick DNA at the concentration as low as 1.0 μM. |
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