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The application of Stille cross-coupling reactions with multiple nitrogen containing heterocycles |
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| Authors: | Roland Selig Dieter SchollmeyerWolfgang Albrecht Stefan Laufer |
| Affiliation: | a Department of Medicinial Chemistry, University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany b Department of Organic Chemistry, University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany c c-a-i-r biosciences GmbH, Paul-Ehrlich-Strasse 15, 72076 Tuebingen, Germany |
| Abstract: | Substituted imidazoles and purine bioisosteres have been widely studied in the literature. We endeavored to combine these heterocyclic core structures into precursors, especially 7-azaindoles, of previously unknown pharmacologically relevant lead structures. A highly flexible synthetic procedure was developed, derived from investigations of the influence of the substrates, solvents, ligand systems, and side reactions. |
| Keywords: | Purine 7-Azaindoles Imidazoles Stille cross-coupling Destannylation |
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