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Asymmetric hydrogenation of alkyl(vinyl)thioethers: a promising approach to α-chiral thioethers |
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| Authors: | Alex F Meindertsma Michael M Pollard Ben L Feringa Johannes G de Vries Adriaan J Minnaard |
| Institution: | aStratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands;bDSM Pharmaceutical Products, Advanced Synthesis, Catalysis and Development, PO Box 18, 6160 MD, Geleen, The Netherlands |
| Abstract: | This paper describes the enantioselective hydrogenation of vinylthioethers. We show that thioether derivatives of maleic esters can be hydrogenated with full conversion and up to 60% ee, and that α-thioether cinnamic acids can be hydrogenated in 51% ee with modest conversion. |
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