Synthesis of small cyclic peptides via reverse turn induced ring closing metathesis of tripeptides |
| |
Authors: | Prabhakaran E N Rao I Nageswara Boruah Anima Iqbal Javed |
| |
Institution: | Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, India. javediqbaldrf@hotmail.com |
| |
Abstract: | A reverse turn induced (gamma/beta-turn) cyclization of tripeptides 1 can be performed in a ring closing metathesis reaction with Grubbs' catalyst to the corresponding cyclic peptides 2. These cyclic peptides may be useful probes as a conformationally constrained mimic of the bioactive conformation of structurally related HIV protease inhibitors. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |