Ultra-fast HPLC-ICP-MS analysis of oxaliplatin in patient urine |
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| Authors: | Gunda Koellensperger Stephan Hann |
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| Affiliation: | (1) Department of Chemistry, Division of Analytical Chemistry, University of Natural Resources and Applied Life Sciences, BOKU, Vienna, Muthgasse 18, 1190 Vienna, Austria; |
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| Abstract: | A novel method for rapid HPLC-ICP-MS analysis of oxaliplatin in human urine was developed implementing a stationary HPLC phase with a particle size of 1.8 μm. The method allowed a cycle time of <1 min at a HPLC flow rate of 0.9 mL min−1. Procedural limits of detection of 0.05 μg L−1 oxaliplatin (150 fg on column) were obtained. Analysis of oxaliplatin in patient urine showed that accurate quantification of the intact drug demanded for storage at −80 °C and rapid measurement after thawing. |
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