Palladium‐Catalyzed Direct C2 Arylation of N‐Substituted Indoles with 1‐Aryltriazenes |
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| Authors: | Can Liu Tao Miao Lei Zhang Prof. Pinhua Li Yicheng Zhang Prof. Lei Wang |
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| Affiliation: | 1. Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000 (P.R. China), Fax: (+86)?561‐3090518;2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032 (P.R. China) |
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| Abstract: | A novel and efficient palladium‐catalyzed C2 arylation of N‐substituted indoles with 1‐aryltriazenes for the synthesis of 2‐arylindoles was developed. In the presence of BF3 ? OEt2 and palladium(II) acetate (Pd(OAc)2), N‐substituted indoles reacted with 1‐aryltriazenes in N,N‐dimethylacetamide (DMAC) to afford the corresponding aryl–indole‐type products in good to excellent yields. |
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| Keywords: | arylation cross‐coupling heterocycles homogeneous catalysis palladium |
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