| 含有1H-1,2,4-三唑咪唑[2,1-b]-1,3,4-噻二唑、 S-三唑[3,4-b]-1,3,4-噻二唑衍生物的合成及生物活性 |
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| 引用本文： | 张艳,刘东,戴朝峰,张自义,许鹏飞,惠新平,王勤.含有1H-1,2,4-三唑咪唑[2,1-b]-1,3,4-噻二唑、 S-三唑[3,4-b]-1,3,4-噻二唑衍生物的合成及生物活性[J].高等学校化学学报,2002,23(10):1882-1886. |
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| 作者姓名： | 张艳 刘东 戴朝峰 张自义 许鹏飞 惠新平 王勤 |
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| 作者单位： | 1. 兰州大学化学化工学院,应用有机化学国家重点实验室
2. 兰州大学生命科学学院,兰州,730000 |
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| 基金项目： | 国家自然科学基金 (批准号 :QT Program)资助 |
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| 摘 要： | 合成了18个含有1H－1，2，4－三唑的咪唑2,1-b]－1，3，4－噻二唑以及S－三唑3,4-b]-1,3,4-噻二唑的稠杂环衍生物，经元素分析及谱学表征，探讨2，5，6－三取代咪唑2,1-b]－1，3，4－噻二唑的可能生成机制。对大肠杆菌、绿脓杆菌、枯草杆菌等初步抑菌试验证明，多数化合物表现了较好的抑菌活性。
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| 关 键 词： | 合成 生物活性 1H－1 2 4－三唑 咪唑[2 1－b]－1 3 4－噻二唑 S－三唑[3 4－b]－1 3 4－噻二唑 抑菌活性 |
| 文章编号： | 0251-0790(2002)10-1882-05 |
Synthesis and Biological Activities of Imidazolo[2,1-b]-1,3,4-thiadiazole, S-Triazole[3,4-b]-1,3,4-thiadiazole Derivatives Bearing 1H-1,2,4-triazole |
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| ZHANG Yan ,LIU Dong ,DAI Chao-Feng ,ZHANG Zi-Yi ,XU Peng-Fei ,HUI Xin-Ping ,WANG Qin.Synthesis and Biological Activities of Imidazolo[2,1-b]-1,3,4-thiadiazole, S-Triazole[3,4-b]-1,3,4-thiadiazole Derivatives Bearing 1H-1,2,4-triazole[J].Chemical Research In Chinese Universities,2002,23(10):1882-1886. |
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| Authors: | ZHANG Yan LIU Dong DAI Chao-Feng ZHANG Zi-Yi XU Peng-Fei HUI Xin-Ping WANG Qin |
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| Institution: | ZHANG Yan 1,LIU Dong 1,DAI Chao-Feng 1,ZHANG Zi-Yi 1*,XU Peng-Fei *,HUI Xin-Ping 1,WANG Qin 2 |
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| Abstract: | Eighteen novel imidazolo-1,3,4-thiadiazoles and S-triazole-1,3,4-thiadiazoles containing 1H-1,2,4-triazole were synthesized and their structures were confirmed by elemental analyses and spectral analysis. And the characteristic data of 1H NMR and MS were explained reasonably. Furthermore, we also proposed the synthetic mechanism of 2,5,6-substituted-imidazolo-1,3,4-thiadiazole. Primary antibacterial test against E.coli, P.aeruginosa, B.subtilis and S.aureus showed that most of them had good antibacterial activities. |
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| Keywords: | 1H-1 2 4-Triazole Imidazolo[2 1-b]-1 3 4-thiadiazole S-triazole[3 4-b]-1 3 4-thiadiazole Antibacterial activities |
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