| 1,4-二羟基蒽醌及其Y~(3+)配位聚合物与DNA相互作用研究 |
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| 引用本文： | 殷卫峰,欧植泽,高云燕,郝平,郭创龙,王中丽.1,4-二羟基蒽醌及其Y~(3+)配位聚合物与DNA相互作用研究[J].化学学报,2010,68(14). |
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| 作者姓名： | 殷卫峰 欧植泽 高云燕 郝平 郭创龙 王中丽 |
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| 作者单位： | 西北工业大学理学院应用化学系,西安,710072 |
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| 基金项目： | 教育部留学同国人员科研启动基金，西北工业大学基础研究基金，西北工业大学翱翔之星 |
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| 摘 要： | 利用紫外-可见吸收光谱(UV-Vis)、核磁共振(1HNMR)、红外光谱(FTIR)研究了1,4-二羟基蒽醌(DHA)与Y3+的配位作用,结果表明Y3+与DHA能形成物质的量之比为1:1的一维链状配位聚合物Y-DHA.与DHA相比,Y-DHA在可见光区的吸收大幅增强,同时具有良好的水溶性.紫外-可见吸收光谱、荧光光谱及DNA熔链温度实验研究结果表明,Y-DHA与CTDNA可通过静电作用和沟槽结合的方式结合,而DHA与CTDNA的作用方式主要为沟槽结合.循环伏安法表明,Y-DHA的还原电位(-0.324VvsSCE)要高于DHA的还原电位(-0.387VvsSCE).无氧条件下,Y-DHA光损伤DNA的能力要明显高于DHA.
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| 关 键 词： | 蒽醌 配位聚合物 DNA光损伤 光诱导电子转移 |
Interaction of 1,4-Dihydroxyanthraquinone and Its Yttrium Coordination Polymer with DNA |
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| Yin Weifeng,Ou Zhize,Gao Yunyan,Hao Ping,Guo Chuanglong,Wang Zhongli.Interaction of 1,4-Dihydroxyanthraquinone and Its Yttrium Coordination Polymer with DNA[J].Acta Chimica Sinica,2010,68(14). |
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| Authors: | Yin Weifeng Ou Zhize Gao Yunyan Hao Ping Guo Chuanglong Wang Zhongli |
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| Institution: | Yin,Weifeng Ou,Zhize* Gao,Yunyan* Hao,Ping Guo,Chuanglong Wang,Zhongli(Department of Applied Chemistry,School of Science,Northwestern Polytechnical University,Xi'an 710072) |
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| Abstract: | The interaction of 1,4-dihydroxyanthraquinone(DHA) with Y3+ was studied by UV-Vis,1H NMR,and FTIR.Y3+ and DHA can form one-dimensional chain coordination polymer Y-DHA with a 1:1 stoichiometry.Y-DHA possesses better water solubility and shows stronger absorption in visible region than DHA.The interaction of Y-DHA and DHA with CT DNA was studied by UV-Vis,fluorescence spectra,and DNA melting temperature experiments.The results indicate that the groove binding and electrostatic interaction are the major modes... |
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| Keywords: | anthraquinone coordination polymer DNA photocleavage photo-induced electron transfer |
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