| 水相中RuCl2(TPPTS)2-(S,S)-DPENDS催化苄叉丙酮的不对称加氢反应 |
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| 引用本文： | 王金波,秦瑞香,熊伟,贾云,刘德蓉,冯建,陈华.水相中RuCl2(TPPTS)2-(S,S)-DPENDS催化苄叉丙酮的不对称加氢反应[J].催化学报,2010,31(3):273-277. |
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| 作者姓名： | 王金波 秦瑞香 熊伟 贾云 刘德蓉 冯建 陈华 |
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| 作者单位： | 1. 重庆科技学院化学化工学院,重庆,401331
2. 四川大学化学学院绿色化学及技术教育部重点实验室,四川成都,610064 |
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| 基金项目： | 国家自然科学基金(20272037);;教育部“春晖计划”(Z2007-1-63016);;重庆市教委基金(KJ081402) |
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| 摘 要： | 将水溶性手性二胺 (S,S)-1,2-二苯基乙二胺二磺酸钠 ((S,S)-DPENDS) 与钌膦配合物 (RuCl2(TPPTS)2]2) 原位生成的催化剂用于催化水相中苄叉丙酮的不对称加氢反应. 在优化条件下, 羰基加氢产物 4-苯基-3-丁烯-2-醇的选择性可达 96.0%, 对映选择性可达 71.2%. 经正己烷简单萃取后即可实现催化剂与加氢产物的分离, 循环使用 5 次后, 目标产物 4-苯基-3-丁烯-2-醇选择性和对映选择性没有明显下降.
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| 关 键 词： | 钌膦配合物 苄叉丙酮 水相 不对称加氢 对映选择性 |
| 收稿时间： | 2010-03-25 |
Asymmetric Hydrogenation of Benzalacetone Catalyzed by RuCl2(TPPTS)2-(S,S)-DPENDS in Water Medium |
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| WANG Jinbo,QIN Ruixiang,XIONG Wei,JIA Yun,LIU Derong,FENG Jian,CHEN Hua.Asymmetric Hydrogenation of Benzalacetone Catalyzed by RuCl2(TPPTS)2-(S,S)-DPENDS in Water Medium[J].Chinese Journal of Catalysis,2010,31(3):273-277. |
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| Authors: | WANG Jinbo QIN Ruixiang XIONG Wei JIA Yun LIU Derong FENG Jian CHEN Hua |
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| Institution: | 1College of Chemistry and Chemical Engineering, Chongqing College of Science and Technology, Chongqing 401331, China 2Key Labora-tory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, China |
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| Abstract: | The asymmetric hydrogenation of benzalacetone catalyzed by ruthenium monophosphine complex RuCl2(TPPTS)2 TPPTS = P(m-C6H4SO3Na)3] modified by (S,S)-DPENDS (disodium salt of sulfonated (S,S)-1,2-diphenyl-1,2-ethylene-diamine) was investigated in a water medium. Under the optimized conditions, a chemoselectivity of 96.0% for 4-phenyl-3-butene-2-ol and ee value of 71.2% were ob-tained. The products could be easily obtained by simple extraction with n-hexane, and the catalyst could be reused five times without... |
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| Keywords: | ruthenium monophosphine complex benzalacetone water medium asymmetric hydrogenation enantioselectivity |
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