Rhodium-catalyzed direct C-H addition of 4,4-dimethyl-2-oxazoline to alkenes |
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| Authors: | Wiedemann Sean H Bergman Robert G Ellman Jonathan A |
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| Affiliation: | Department of Chemistry, University of California Berkeley, California 94720, USA. |
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| Abstract: | A new method for the preparation of 2-substituted oxazolines by rhodium-catalyzed coupling of alkenes with 4,4-dimethyl-2-oxazoline is reported. The oxazoline products are obtained in good yield with excellent selectivity for the linear product. A variety of alkene substitution patterns and functional groups are tolerated. This procedure represents an attractive alternative to hydroesterification because it does not involve the manipulation of CO gas. |
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