三环己基锡邻(二茂铁甲酰基)苯甲酸酯配位聚合物的微波固相合成、晶体结构及性能

在微波辐射下, 邻二茂铁甲酰基苯甲酸与三环己基氢氧化锡反应, 合成了结构新颖的含铁锡多核配合物. 紫外光谱、 红外光谱、 核磁共振谱、 元素分析和X射线晶体衍射表征结果表明, 配合物的中心锡与配基原子形成五配位畸变三角双锥构型, 通过配体的羧基氧和羰基氧原子分别与锡原子连接形成一维链配位聚合物. 热分析结果表明, 配合物在163 ℃以下具有较好的热稳定性. 其溶液在电极上能准可逆电子转移, 对人体细胞HT-29, MCF-7, HepG2, KB和A549的体外抗癌活性均高于对照药顺铂, 具有潜在应用价值.

Microwave Assisted Solid-state Synthesis,Crystal Structure,Properties of the Coordination Polymer Constructed from Tricyclohexyltin Hydroxide and o-Ferrocenylcarbonyl Benzoic Acid†

A novel coordination polymer tricyclohexyltin(o-ferrocenylcarbonyl) benzoate was synthesized by the reaction of tricyclohexyltin hydroxide with o-ferrocenylcarbonyl benzoic acid under microwave irradiation. It was characterized by UV, IR, ¹H and ¹³C NMR, elemental analysis and X-ray crystal diffraction. The crystal structure shows a distorted trigonal bipyramidal configuration with five-coordination for the central tin atom. The tin atoms and the oxygen atoms of C(O)—O and from the o-ferrocenylcarbonyl benzoate are interconnected to form a one-dimensional coordination polymer chain. The thermal studies showed that complex exhibited higher thermal stability. Electrochemical studies of the complex have been made in EtOH/H₂O by cyclic voltammetry. The complex shows quasi reversible electron transfer process. The in vitro antitumour activity of the complex was tested.The results show that the complex exhibits better antitumour activity in vitro against HT-29, MCF-7, HepG2, KB and A549 tumour cells. So the complex may have potential applications.