Ugi reaction for the synthesis of 4-aminopiperidine-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil |
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| Authors: | Sandra Malaquin Guillaume Laconde |
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| Affiliation: | Biostructures and Drug Discovery, INSERM U761, Faculté de Pharmacie, Université Lille Nord de France, Lille F-59006, France PRIM Pôle de Recherche Interdisciplinaire sur le Médicament, Lille F-59000, France |
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| Abstract: | A two-step sequence involving an Ugi four-component reaction was developed for the preparation of 4-aminopiperidine-4-carboxylic acid derivatives. This strategy has led to the successful preparation of two drugs carfentanil and remifentanil in shorter times and better yields than previously described methods. |
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| Keywords: | Ugi reaction Remifentanil Carfentanil Mumm rearrangement |
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