Synthesis and in vitro evaluation of taxol oxetane ring D precursors |
| |
Authors: | Rü diger Kaspera,Jonathan L. Cape,Raymond E.B. Ketchum |
| |
Affiliation: | a Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340, United States b Department of Chemistry, Washington State University, Pullman, WA 99164-4630, United States c Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, United States |
| |
Abstract: | A series of potential taxoid substrates was prepared in radiolabeled form to probe in vitro for the oxirane formation step and subsequent ring expansion step to the oxetane (ring D) presumably involved in the biosynthesis of the anticancer agent Taxol. None of the taxoid test substrates underwent transformation in cell-free systems from Taxus suggesting that these surrogates bore substitution patterns inappropriate for recognition or catalysis by the target enzymes, or that taxoid oxiranes and oxetanes arise by independent biosynthetic pathways. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|