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CuCl-catalyzed cycloaddition of 1,3-butadiynes with primary amines: an atom-economic process for synthesis of 1,2,5-trisubsituted pyrroles |
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| Authors: | Qingwei Zheng |
| Affiliation: | a Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
| Abstract: | 1,3-Butadiynes underwent inter- and intramolecular double hydroamination with primary amines in the presence of CuCl at 100 °C to afford 1,2,5-trisubsituted pyrroles in good to high yields. |
| Keywords: | Amine 1,3-Butadiyne Cycloaddition Cuprous chloride Pyrrole |
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