Synthetic approaches to 5,7-disubstituted imidazo[5,1-f][1,2,4]triazin-4-amines |
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| Authors: | Douglas S. Werner Hanqing Dong Mridula Kadalbajoo Radoslaw S. Laufer Paula A. Tavares-Greco Brian R. Volk Mark J. Mulvihill Andrew P. Crew |
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| Affiliation: | Department of Cancer Chemistry, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA |
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| Abstract: | ![]()
The preparation of 5,7-disubstituted imidazo[5,1-f][1,2,4]triazin-4-amines, exemplified by 5-[3-(benzyloxy)phenyl]-7-cyclobutylimidazo[5,1-f][1,2,4]triazin-4-amine, was developed through a linear and three convergent synthetic strategies, with the latter providing the greatest flexibility for diversification at the 5-position at the last step of the synthesis. |
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