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Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims |
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| Authors: | Pavel Nagorny Jón T Njardarson Christoph Gaul Ouathek Ouerfelli |
| Institution: | a Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA b Organic Synthesis Core Facility, 1275 York Avenue, New York, NY 10065, USA c Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA 02453, USA d Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA e Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027, USA |
| Abstract: | In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the ‘small molecule’ co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer. |
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