| 苯并吡喃[3,4-c]吡啶-5-酮类化合物的合成 |
| |
| 引用本文： | 李谷才,尹端沚,沈玉梅,汪勇先.苯并吡喃[3,4-c]吡啶-5-酮类化合物的合成[J].有机化学,2006,26(6):852-855. |
| |
| 作者姓名： | 李谷才 尹端沚 沈玉梅 汪勇先 |
| |
| 作者单位： | 中国科学院上海应用物理研究所,放射性药物研究中心,上海,201800 |
| |
| 基金项目： | 国家自然科学基金(No.30371634)，中国科学院创新工程重大(No.KJCXI-SW-08)资助项目. |
| |
| 摘 要： | 以4-酮-3-甲酸甲酯哌啶盐酸盐为原料, 通过分子间环加成和N-烷基化反应, 合成了一系列潜在的多巴胺D4受体配基苯并吡喃3,4-c]吡啶-5-酮类化合物, 并用1H NMR, IR, ESI-MS, 元素分析对其进行了表征.
|
| 关 键 词： | 苯并吡喃[3 4-c]吡啶-5-酮 多巴胺D4受体 合成 表征 |
| 收稿时间： | 04 13 2005 12:00AM |
| 修稿时间： | 12 16 2005 12:00AM |
Synthesis of Chromeno[3,4-c]pyridin-5-ones |
| |
| LI, Gu-Cai,YIN, Duan-Zhi,SHEN, Yu-Mei,WANG, Yong-Xian.Synthesis of Chromeno[3,4-c]pyridin-5-ones[J].Chinese Journal of Organic Chemistry,2006,26(6):852-855. |
| |
| Authors: | LI Gu-Cai YIN Duan-Zhi SHEN Yu-Mei WANG Yong-Xian |
| |
| Institution: | Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 |
| |
| Abstract: | A series of novel chromeno3,4-c]pyridin-5-ones as potential dopamine D4 receptor ligands were prepared from proper phenols and methyl-4-oxo-3-piperidine carboxylate hydrochloride through intermo-lecular cycloaddition and N-alkylation reaction.Their structures were confirmed by elemental analysis,IR,1H NMR and ESI-MS spectra. |
| |
| Keywords: | chromeno[3 4-c]pyridin-5-one dopamine D4 receptor synthesis characterization |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
| 点击此处可从《有机化学》下载免费的PDF全文 |
|
