Expanding the repertoire of pyrrolidyl PNA analogues for DNA/RNA hybridization selectivity: aminoethylpyrrolidinone PNA (aepone-PNA) |
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| Authors: | Sharma Nagendra K Ganesh Krishna N |
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| Institution: | Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India. |
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| Abstract: | New PNA analogues derived from aminoethylpyrrolidin-5-one backbone show stabilization of aepone-PNA:DNA hybrids and destabilization of the corresponding RNA hybrids compared to unmodified PNA. |
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