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Gadolinium-binding helix-turn-helix peptides: DNA-dependent MRI contrast agents |
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| Authors: | Caravan Peter Greenwood Jaclyn M Welch Joel T Franklin Sonya J |
| Institution: | EPIX Medical, Inc., 71 Rogers Street, Cambridge, MA 02142, USA. |
| Abstract: | A de novo designed gadolinium metallopeptide was found to be a very efficient relaxation agent, with 100% increase in relaxivity upon binding to DNA. |
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