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Total Synthesis of (+)‐Dibromophakellin and (+)‐Dibromophakellstatin |
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| Authors: | Takuya Imaoka Takafumi Akimoto Osamu Iwamoto Kazuo Nagasawa Prof. Dr. |
| Affiliation: | Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2‐24‐16 Naka‐cho, Koganei, Tokyo 184‐8588 (Japan), Fax: (+81)?42‐388‐7295 |
| Abstract: | A new method for the preparation of quaternary chiral aminals has been developed that employs an enamide‐type Overman rearrangement process. This methodology was applied to enantioselective total syntheses of (+)‐dibromophakellin and (+)‐dibromophakellstatin. |
| Keywords: | aminals enamides natural products Overman rearrangement total synthesis |