Enantioseparation of the New Antifungal Drug Iodiconazole and Structurally Related Triadimenol Analogues by CE with Neutral Cyclodextrin Additives |
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| Authors: | Wuhong Li Liang Zhao Guangguo Tan Chunquan Sheng Xinrong Zhang Zhenyu Zhu Guoqing Zhang Yifeng Chai |
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| Institution: | 1. School of Pharmacy, Second Military Medical University, Shanghai, 200433, China
2. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200433, China
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| Abstract: | Chiral separation of iodiconazole, a new antifungal drug, and 12 new structurally related triadimenol analogues were studied by capillary electrophoresis with seven neutral cyclodextrins. It was found that hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was the most effective chiral selector. Furthermore, the influence of the concentration of HP-γ-CD, buffer pH, buffer concentration, temperature, and applied voltage was investigated, and the method was validated. The study of the analyte structure-enantioseparation relationships showed that substitutions in the side chains had important influences on enantiomeric separation. |
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