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tert-Butylthiacalix[4]arene monolayers as a biomimetic model for the oxidation of antioxidants with cytochrome c |
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| Authors: | N B Mel’nikova E N Kochetkov S E Solov’eva E V Popova I S Antipin A E Bol’shakova O E Zhil’tsova A I Konovalov |
| Institution: | 1. Nizhny Novgorod State Medical Academy, 10/1 pl. Minina, 603600, Nizhny Novgorod, Russian Federation 2. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, 8 ul. Akad. Arbuzova, 420088, Kazan, Russian Federation |
| Abstract: | The possibility of designing a model of sensor to antioxidants based on thiacalix4]arene monolayers with immobilized cytochrome c was shown. The molecular surface area S 0 of thiacalix4]arene in the monolayers and the surface pressure coefficient ?dπ/dS (elasticity) reflect changes in the redox state of cytochrome c in the presence of dihydroquercetin and ascorbic acid in the aqueous subphase. The absorption spectra in the visible and UV ranges of solutions of the subphase and transferred thiacalix4]arene monolayers with immobilized cytochrome c confirm the oxidation of the antioxidants to quinones and formation of the reduced form of cytochrome c. |
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