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Total Synthesis of (+)‐Cryptocaryalactone and of a Diastereoisomer of (+)‐Strictifolione via Ring‐Closing Metathesis (RCM) and Olefin Cross‐Metathesis (CM) |
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| Authors: | Gowravaram Sabitha Bhaskar Vangala S Siva Sankara Reddy Jhillu S Yadav |
| Institution: | Organic Division‐I, Indian Institute of Chemical Technology, Hyderabad – 500?007, India, (fax: +91‐40‐27160512) |
| Abstract: | Ring‐closing metathesis (RCM) and olefin cross‐metathesis (CM) reactions were used as the key steps for the synthesis of (+)‐cryptocaryalactone ( 1 ) and the first synthesis of the diastereoisomer 3 of (+)‐strictifolione, starting from the commercially available L ‐malic acid (=(2S)‐2‐hydroxybutanedioic acid). |
| Keywords: | Ring‐closing metathesis Olefin cross‐metathesis Strictifolione Cryptocaryalactone Grubbs catalyst |