具有垂直孔道的壳聚糖乳酸盐海绵的制备及体外释药模型的拟合分析

先将壳聚糖(CH)经乳酸改性制成壳聚糖乳酸盐(LCH)以改善其溶解性, 然后通过加入冰晶生长引导剂叔丁醇(TBA), 在特制的定向冷冻装置中冻结, 再经冷冻干燥后, 制成了一种圆柱形的海绵体, 其内部具有垂直方向上的孔道结构. 通过控制叔丁醇的浓度, 制备了具有不同孔径及孔隙率的海绵样品. 以红霉素为模型药物, 研究了具有自身降解溶蚀功能的LCH样品的体外释药模型, 结果表明, LCH样品的释药过程主要分为基体溶蚀控释和药物后扩散2个阶段. 其中基体控释阶段符合Couarraze释药模型.

Preparation of Chitosan Lactate Sponges with Uniform Vertical Pores and Fitted Analysis of Release Medicine Model in vitro

Chitosan lactate(LCH) was obtained by reacting with lactic acid based on chitosan(CH).The products were found to be superior to original chitosan as far as water solubility was concerned.With the structure-directing agent tertiary butyl alcohol(TBA) in the vertical temperature controlled device,uniform and vertical pores structure in sponges were obtained upon freeze-drying.Different diameter form sponge samples were made by controlling the concentration of TBA.Then,drug delivering model of sponges samples with degradation and dissolution function was studied with erythromycin as model drug in vitro.The results demonstrate that drug delivering process of sponge samples is divided into two stages: matrix dissolution controlled-release stage and drug after-diffusion stage.Matrix dissolution controlled-release stage is very good to fit the couarraze drug delivering model.