| 黄酮类药物与氯金酸的作用及其分析应用 |
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| 引用本文： | 王慧娟,李春梅,刘跃,李原芳.黄酮类药物与氯金酸的作用及其分析应用[J].高等学校化学学报,2012,33(6):1172-1176. |
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| 作者姓名： | 王慧娟 李春梅 刘跃 李原芳 |
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| 作者单位： | 发光与实时分析教育部重点实验室, 西南大学化学化工学院, 重庆 400715 |
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| 基金项目： | 国家"重大新药创制"科技重大专项，国家自然科学基金，重庆市自然科学基金 |
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| 摘 要： | 将4种黄酮类药物染料木素、木犀草素、大豆素及柚皮素与氯金酸在不同酸度条件下反应形成金纳米颗粒. 研究发现, 生成的金纳米颗粒的等离子体共振吸收信号与4种黄酮类药物的浓度呈线性关系, 从而建立了这4种典型黄酮类药物的测定方法. 分析了黄酮类药物的分子结构并利用Materials-studio 4.0软件计算了各原子的电子云密度分布. 结果表明, 4种黄酮类药物与氯金酸作用的适宜酸度与黄酮类化合物结构中的酚羟基数和碱性氧的电子云密度分布有关.
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| 关 键 词： | 染料木素 木犀草素 大豆素 柚皮素 金纳米颗粒 等离子体共振吸收 |
| 收稿时间： | 2011-07-21 |
Redox of Flavonoids with Chlorauric Acid and Its Analytical Application |
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| WANG Hui-Juan
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LI Chun-Mei
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LIU Yue
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LI Yuan-Fang.Redox of Flavonoids with Chlorauric Acid and Its Analytical Application[J].Chemical Research In Chinese Universities,2012,33(6):1172-1176. |
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| Authors: | WANG Hui-Juan LI Chun-Mei LIU Yue LI Yuan-Fang |
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| Institution: | Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China |
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| Abstract: | Four flavonoids including genistein,luteolin,daidzein and naringenin can reduce HAuCl4 to form gold nanoparticles in different acidity.There are good linear correlations between the signal of plasmon resonance absorption of gold nanoparticles and the concentration of four flavonoids.Thus,we developed a method to detect these four flavonoids respectively.By analyzing the molecular structure and calculating the electron cloud density distribution of the atoms using Materials-studio 4.0,we found that suitable pH for the reaction of different flavonoids and HAuCl4 was related to the number of phenolic hydroxyl group of flavonoid and electron cloud density distribution of alkaline oxygen atoms. |
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| Keywords: | Genistein Luteolin Daidzein Naringenin Gold nanoparticles Plasmon resonance absorption |
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