| 肌肉醇取代苯甲酸盐的合成及生物活性 |
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| 引用本文： | 曾振芳,孙晓红,刘源发,黄秋婵.肌肉醇取代苯甲酸盐的合成及生物活性[J].化学研究与应用,2012(2):231-236. |
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| 作者姓名： | 曾振芳 孙晓红 刘源发 黄秋婵 |
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| 作者单位： | 广西民族师范学院化学与生物工程系;西北大学化工学院化学研究所;西北大学化学与材料学院 |
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| 摘 要： | 本文以硫脲和硫酸二甲酯为原料反应生成S-甲基异硫脲硫酸盐,再与2-甲基氨基乙醇反应生成肌肉醇硫酸盐,分离出肌肉醇碱,最后与具有生物活性的取代苯甲酸反应生成了7种肌肉醇取代苯甲酸盐。化合物结构经IR,1H NMR和元素分析进行表征,初步室内生测结果表明该类化合物具有一定的抑菌活性。
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| 关 键 词： | 肌肉醇盐 取代苯甲酸 生物活性 合成 |
Synthesis and biological activities of creatinol substituted benzoic acids |
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| ZENG Zhen-fang,SUN Xiao-hong,LIU Yuan-fa,HUANG Qiu-chan.Synthesis and biological activities of creatinol substituted benzoic acids[J].Chemical Research and Application,2012(2):231-236. |
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| Authors: | ZENG Zhen-fang SUN Xiao-hong LIU Yuan-fa HUANG Qiu-chan |
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| Institution: | 1(1.Department of Chemistry and Biological Engineering,Guangxi Normal Univerity for Nationalities,Chongzuo 532200,China; 2.Chemical Research Institute,College of Chemical Engineering,Northwest University,Xi’an 710069,China; 3.College of Chemistry&Materials Science,Northwest University,Xi’an 710069,China) |
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| Abstract: | In this paper,S-methyl-iso-thiourea sulfate was synthesized using thiourea and dimethyl sulfate as starting materials.The creatinol sulfate was prepared by S-methyl-iso-thiourea sulfate and 2-methylaminoethanol.The base creatinol was liberated.Seven creatinol salts were obtained by the base creatinol reacting with biological substituted benzoic acids.Their structures had been determined by IR,1H NMR and elemental analysis.The preliminary biological activities had been tested.The results showed that most of them exhibited fungus-inhibiting. |
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| Keywords: | creatinol salt substituted benzoic acid biological activity synthesis |
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