| 液相色谱/质谱/质谱联用法测定乌头属药材及中成药中乌头类生物硷含量 |
| |
| 引用本文： | 王兆基,何绍基,徐树棋.液相色谱/质谱/质谱联用法测定乌头属药材及中成药中乌头类生物硷含量[J].分析化学,2001,49(4):391-395. |
| |
| 作者姓名： | 王兆基 何绍基 徐树棋 |
| |
| 作者单位： | 香港政府化验所, |
| |
| 摘 要： | 探讨了用LC／MS／MS联用法测定乌头属药材及有关中成药中乌头硷、次乌头硷和中乌头硷含量的方法。应用优化后的技术条件及采用多反应监测扫描方式，结果表明分析样品中各乌头硷浓度在0．5－40mg/L范围内，色谱峰面积与浓度有良好的线性关系。此法亦应用于14个不同的乌头属药材及10个不同的中成药样品加的乌头硷含量检测。
|
| 关 键 词： | 液相色谱 质谱 联用技术 乌头硷 乌头属药材 中成药 生物硷 中药分析 |
Determination of Aconitine alkaloids in Aconitum Plants andRelated Proprietary Medicines byLiquid Chromatography/Mass Spectrometry/Mass Spectrometry |
| |
| Wang Zhaoji,He Shaoji,Xu Shuqi.Determination of Aconitine alkaloids in Aconitum Plants andRelated Proprietary Medicines byLiquid Chromatography/Mass Spectrometry/Mass Spectrometry[J].Chinese Journal of Analytical Chemistry,2001,49(4):391-395. |
| |
| Authors: | Wang Zhaoji He Shaoji Xu Shuqi |
| |
| Abstract: | A liquid chromatography/mass spectrometry/mass spectrometric method was developed for the determination of aconitine, mesaconitine and hypaconitine in root tuber of sevral species of Aconitum plants and related proprietary medicines. With the use of the optimized instrumental conditions and the Multiple Reaction Monitoring (MRM) technique, good linearity was obtained for the alkaloids in concentrations ranged from 0.5 to 40 mg/L. The method was applied to the analysis of 14 samples of various species of Aconitum plants and 10 different proprietary medicine samples. |
| |
| Keywords: | Liquid chromatography-mass spectrometry aconitine alkaloids aconitum plants proprietary medicine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
