Concise synthesis of anhydrovinblastine from leurosine |
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| Authors: | Hardouin Christophe Doris Eric Rousseau Bernard Mioskowski Charles |
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| Institution: | CEA/Saclay, Service de Marquage Moléculaire et de Chimie Bioorganique, Bat. 547, Département de Biologie Joliot-Curie, 91191 Gif sur Yvette Cedex, France. |
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| Abstract: | reaction: see text] The Cp(2)TiCl-mediated deoxygenation of leurosine (1) afforded anhydrovinblastine (4) in good yield. Furthermore, as the reaction proceeded via a carbon-centered radical intermediate, this transient was also trapped by a hydrogen-atom donor to afford selectively reduced alkaloid 10. |
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