Separation of R(+)-and S(-)-Benzyl-3-Tetrahydrofuroates Using Two Different Chiral Columns |
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Abstract: | Abstract A chiral separation of N(+)-and S(-)-benzyl-3-tetrahydrofuroate (I) and p-nitrobenzyl-3-tetrahydrofuroate (II) using a Chiralcel OB© (cellulose tribenzoate) column with a hexane/2-propanol (60:40 v/v) mobile phase is described. Enantiomeric purity of R(+)-I was evaluated using the same chromatographic conditions. I was also separated using a Chiralspher© (polyamides bonded to silica gel) column with an ethanol/distilled water (50:50 v/v) mobile phase. |
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