Synthesis of (‐)‐herbertenediol and (aR,aS)‐mastigophorenes A via asymmetric intramolecular heck coupling reaction

Total enantioselective synthesis of the natural (‐)‐Herbertenediol (1) was accomplished in eleven steps with an overall yield of 15% starting from the 2‐methoxy‐4‐methyl‐phenol. The total synthesis features asymmetric intramolecular Heck reaction and Wolff‐Kishner‐Huang reduction. (aR, aS)‐Mastigophorenes A was also synthesized through the oxidative coupling reaction.