First total synthesis of (±)-puyanin and (±)-4'-O-methylbonannione

<正>A facile approach for the first total synthesis of two naturally occurring geranylated flavonoids,(±)-puyanin 1 and(±)-4'-O- methylbonannione 2 has been obtained with total yield 27%and 21%,respectively.The key steps were regioselective cyclization of geranylated trihydroxychalcone and regioselective geranylation of 2,4,6-trihydroxyacetophenone.