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Enantioselective Iridium‐Catalyzed Allylation of Acetylenic Ketones via 2‐Propanol‐Mediated Reductive Coupling of Allyl Acetate: C14‐C23 of Pladienolide D |
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| Authors: | Gilmar A. Brito Woo‐Ok Jung Minjin Yoo Michael J. Krische |
| Abstract: | Highly enantioselective catalytic reductive coupling of allyl acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or aromatic ketones. This method was used to construct C14‐C23 of pladienolide D in half the steps previously required. |
| Keywords: | Enantioselektivitä t Iridium Ketonallylierung Transferhydrierung π -Allyl |