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Synthesis studies directed toward gelsemine. A new synthesis of highly functionalized cis-hydroisoquinolines
Affiliation:1. Shanghai Key Lab of Chemistry Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;2. Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China;1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China;2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China;3. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China;1. Department of Chemistry, R.T.M. Nagpur University, Nagpur 440033, India;2. Department of Chemistry, National College, Tiruchirappalli 620001, India;1. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, PR China;2. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, 450001, PR China;3. People''s Hospital of Zhengzhou, Zhengzhou 450053, PR China;1. National University of Pharmacy, Pushkinska Str. 53, Kharkiv 61001, Ukraine;2. STC Institute for Single Crystals, National Academy of Sciences of Ukraine, Lenin Ave. 60, Kharkiv 61001, Ukraine;1. Departamento de Química Orgánica, Facultad de Química, Universidad de Murcia, Campus de Espinardo, 30071 Murcia, Spain;2. Departamento de Química Física, Facultad de Química, Universidad de Murcia, Campus de Espinardo, 30071 Murcia, Spain
Abstract:
Cis-Hydroisoquinolines can be prepared in good yields by treatment of readily available endo-1-(cyanomethyl)-6-hydroxybicyclo [2.2.2]oct-5-en-1-yl amines with KH as summarized in Scheme 3.
Keywords:
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