A stereocontrolled access to vicinal difluoroalkanes |
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| Affiliation: | 1. Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing 100083, China;2. School of Materials Science and Engineering, Shenyang Jianzhu University, Shenyang 110168, China;3. Geosciences Department, University of Wisconsin – Parkside, Kenosha, WI 53144, USA;4. Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Science, Beijing 100083, China;1. School of Chemical Sciences, University of Auckland, 23 Symonds St, Auckland, New Zealand;2. Centre for Green Chemical Science, School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand;1. Centro de Física de Materiales (CSIC, UPV/EHU) and Materials Physics Center MPC, Paseo Manuel de Lardizabal 5, E-20018, San Sebastián, Spain;2. Donostia International Physics Center (DIPC), Paseo Manuel de Lardizabal 4, E-20018, San Sebastián, Spain;3. Departamento de Física de Materiales, Universidad del País Vasco (UPV/EHU), Apartado 1072, E-20800, San Sebastián, Spain;4. IKERBASQUE - Basque Foundation for Science, María Díaz de Haro 3, E-48013, Bilbao, Spain |
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| Abstract: | ![]()
An expedient method for the preparation of diastereomerically and, by extension, even enantiomerically pure vicinal difluoroalkanes is described. The two fluorine atoms are introduced in two consecutive steps : ring opening of an oxirane by addition of hydrogen fluoride and subsequent treatment of the resulting fluorohydrine with diethylaminosulfur trifluoride. |
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