Synthesis of chiral α-amino acids |
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| Authors: | Tushar K Chakraborty Animesh Ghosh |
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| Abstract: | A novel method for the synthesis of chiral α-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans’ method in the α-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. |
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| Keywords: | α -amino acids Hofmann rearrangement oxazolidinone Evans’ reaction |
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