Chiral squaramide-catalyzed highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes |
| |
Authors: | Yang Wen Du Da-Ming |
| |
Institution: | School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, People's Republic of China. |
| |
Abstract: | An efficient highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes catalyzed by chiral squaramide catalyst has been developed. This organocatalytic reaction with a low catalyst loading (2 mol%) proceeded well to afford synthetically useful 1,3-dinitro compounds in high yields with high diastereoselectivities (up to 95 : 5 dr) and excellent enantioselectivities (up to 97% ee). |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|