Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides |
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| Authors: | Codée Jeroen D C Litjens Remy E J N den Heeten René Overkleeft Herman S van Boom Jacques H van der Marel Gijs A |
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| Institution: | Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands. |
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| Abstract: | Diphenylsulfoxide in combination with triflic anhydride provides a very potent thiophilic glycosylation promotor system, capable of activating disarmed thioglycosides. The usefulness of this novel thiophilic activator is illustrated in a successful chemoselective glycosylation sequence in which the donor thioglycoside in the first condensation step may be either armed or disarmed. reaction: see text] |
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