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Short Total Synthesis of Ajoene |
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| Authors: | Filipa Silva Dr. Shaista S. Khokhar Danielle M. Williams Dr. Robert Saunders Dr. Gareth J. S. Evans Michael Graz Prof. Dr. Thomas Wirth |
| Affiliation: | 1. School of Chemistry, Cardiff University, Cardiff, UK;2. Neem Biotech, Abertillery, UK |
| Abstract: | We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable procedure for the synthesis of ajoene from simple building blocks that is also suitable for upscale operations. |
| Keywords: | ajoene allicin garlic organosulfur compounds selenoxide elimination |