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Iridium‐Catalyzed Reductive Alkylations of Secondary Amides |
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| Authors: | Dr Wei Ou Feng Han Xiu‐Ning Hu Hang Chen Prof?Dr Pei‐Qiang Huang |
| Institution: | 1. Department of Chemistry, Fujian Provincial Key Laboratory of Chemical Biology, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, P. R. China;2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P. R. China |
| Abstract: | Reported herein is the first direct, metal‐catalyzed reductive functionalization of secondary amides to give functionalized amines and heterocycles. The method is shown to have exceptionally broad scope with respect to suitable nucleophiles, which cover both hard and soft C nucleophiles as well as a P nucleophile. The reaction exhibits good chemoselectivity and tolerates several sensitive functional groups. |
| Keywords: | amides homogeneous catalysis iridium reductive alkylation synthetic methods |