| Formal synthesis of（＋）-tashiromine and study toward the total synthesis of（＋）-stemoamide |
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| 作者姓名： | Yue-Jie Chen Rui-Yang Bao Xiao-Dong Zhang Ye-Feng Tang |
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| 作者单位： | The Comprehensive AIDS Research Center, Department of Pharmacology ＆ Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084,China |
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| 基金项目： | the financial supports from Beijing Natural Science Foundation （No. 2132037）; NSFC （Nos. 21102081, 21272133）; New Teachers’ Fund for Doctor Stations Ministry of Education （No. 20110002120011）; Scientifc Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education （No. 20121027968） |
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| 摘 要： | An effcient formal synthesis of（＋）-tashiromine was achieved by employing an intermolecular asymmetric Mannich-type reaction as the key step.Concurrently,a novel approach toward the total synthesis of（＋）-stemoamide through dyotropic rearrangement of 3,4-cis-b-lactone was also explored.
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| 关 键 词： | 全合成 不对称 分子间 内酯 顺式 |
| 收稿时间： | 26 April 2013 |
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