| An expedient one-pot synthesis of highly substituted imidazoles using supported ionic liquid-like phase（SILLP） as a green and effcient catalyst and evaluation of their anti-microbial activity |
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| 作者姓名： | Maryam Saffari Jourshari Manouchehr Mamaghani Farhad Shirini Khalil Tabatabaeian Mehdi Rassa Hadiss Langari |
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| 作者单位： | [1]Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, lran [2]Departrnent of Biology, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, lran |
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| 基金项目： | the Research Council of University of Guilan for the financial support |
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| 摘 要： | An effcient method for the synthesis of imidazole derivatives by a three-component condensation of benzil or 9,10-phenanthrenequinone,aldehydes and ammonium acetate using supported ionic liquidlike phase（SILLP）catalyst under ultrasonic irradiation or classical heating conditions is reported.The present methodology offers several advantages,such as excellent yields,simple procedures,short reaction times,simple work-up and mild conditions.The catalyst is easily separated from the products by fltration and also exhibits remarkable reusable activity.These highly substituted imidazoles were also evaluated for their anti-microbial activity.
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| 关 键 词： | 抗微生物活性 离子液体 取代咪唑 一锅合成 催化剂 评价 负载 超声波照射 |
| 收稿时间： | 7 April 2013 |
An expedient one-pot synthesis of highly substituted imidazoles using supported ionic liquid-like phase（SILLP） as a green and effcient catalyst and evaluation of their anti-microbial activity |
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| Maryam Saffari Jourshari,Manouchehr Mamaghani,Farhad Shirini,Khalil Tabatabaeian,Mehdi Rassa,Hadiss Langari.An expedient one-pot synthesis of highly substituted imidazoles using supported ionic liquid-like phase（SILLP） as a green and effcient catalyst and evaluation of their anti-microbial activity[J].Chinese Chemical Letters,2013,24(11):993-996. |
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| Authors: | 《Chinese Chemical Letters》 |
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| Institution: | 1. Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran;2. Department of Biology, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran |
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| Abstract: | An efficient method for the synthesis of imidazole derivatives by a three-component condensation of benzil or 9,10-phenanthrenequinone, aldehydes and ammonium acetate using supported ionic liquid-like phase (SILLP) catalyst under ultrasonic irradiation or classical heating conditions is reported. The present methodology offers several advantages, such as excellent yields, simple procedures, short reaction times, simple work-up and mild conditions. The catalyst is easily separated from the products by filtration and also exhibits remarkable reusable activity. These highly substituted imidazoles were also evaluated for their anti-microbial activity. |
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| Keywords: | SILLP Imidazole Phenanthroimidazole Ionic liquid Three-component reaction Anti-microbial activities |
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